Abstract
A series of highly potent and selective PPARdelta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 microM, making it a useful tool in studying the biological effects of selective PPARdelta activation.
MeSH terms
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Butyrates / chemistry*
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Butyrates / metabolism*
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Ligands
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Models, Molecular
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Molecular Structure
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PPAR delta / agonists*
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PPAR delta / chemistry
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PPAR delta / metabolism*
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Phenylurea Compounds / chemistry*
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Phenylurea Compounds / metabolism*
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Structure-Activity Relationship
Substances
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Butyrates
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GW 2433
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Ligands
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PPAR delta
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Phenylurea Compounds